Animal Models of Pain

Animal models of pain are meant to mirror perceptual events that can occur in the clinical setting.  Pain, in humans, is derived from a group of specialized receptors in tissue, modified by spinal and supraspinal mechanisms, and integrated into a discrete sensory experience with an emotional valence in the brain1. The use of animals, allows for the complex study of the multidimensional nature of pain.  Measuring pain endpoints in animals is as varied as the models used for induction and are generally multifaceted, allowing for the capture of multiple pain “experiences” in the same test subjects.

 

1 – Gregory NS, Harris AL, Robinson CR, Dougherty PM, Fuchs PN, Sluka KA. An overview of animal models of pain: disease models and outcome measures. J Pain. 2013;14(11):1255–1269. doi:10.1016/j.jpain.2013.06.008

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