Partial Lateral Meniscectomy Induced OA in Rabbits

Overview of the Partial lateral meniscectomy surgery:

Partial meniscectomy surgery in New Zealand White rabbits (approximately 4 kg) results in lesions resembling those occurring in human OA. Rabbits unlike rats, mice and guinea pigs, preferentially load the lateral aspect of the knee joint. Partial meniscectomy surgery on the medial aspect of the joint generally results in relatively mild to moderate degenerative changes and this model has been used extensively for testing of potential chondroprotective agents. Partial lateral meniscectomy induces a very consistent focal degenerative change involving approximately 1/2 of the lateral tibial plateau and femoral condyle. If the surgeon is consistent in removing the same size piece of meniscus from the same location on the lateral side and the histotechnologist is consistent in the sectioning process, the lesions are remarkably similar between animals at 6 weeks post- surgery. The surgical procedure involves transection of the fibular collateral ligament prior to entry into the joint space.

References:

Bendele AM.  Animal models of osteoarthritis. J Musculoskelet Neuronal Interact. 2001 Jun;1(4):363-76.

Bendele AM. Animal models of osteoarthritis in an era of molecular biology. J Musculoskelet Neuronal Interact. 2002 Dec;2(6):501-3.

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